ABSTRACT
Background Due to the limitation of drug treatment and other adverse reactions, many psychological treatments always adopt rehabilitation training or non-drug intervention methods, while physical exercise is considered as an auxiliary way. A mass of literature has verified the therapeutic benefits of physical exercise to reduce depression and anxiety in clinical populations. However, little attention is paid to the mental health benefits of exercise for non-clinical populations. The purpose of this meta-analysis is to systematically aggregate and quantify findings of the effect of physical exercise on depression and anxiety in non-clinical populations, through which to evaluate whether physical exercise intervention as a non-drug means can effectively improve the depressive and anxious moods of college students. Significance This paper combines sport and psychotherapy and links kinesiology and psychology, which can deepen readers' understanding and stimulate their interest in the practice of sport and exercise psychology. The 2019 novel coronavirus disease (COVID-19) has swept the world, causing a global epidemic with serious physical and psychological consequences, and this study may help policymakers and health care professionals to make effective recommendations for psychological interventions for college students. Methods The study was based on five electronic databases: CNKI, Wan Fang Data, SinoMed, PubMed, and Web of Science. The quality of the selected articles was evaluated by the PEDro scale. The Meta-Analysis was performed using R-4.0.4, which computed pooled estimates of effect size and respective 95% confidence intervals (95% CI) for intervention. Bias and sensitivity analyses were calculated to explore the source of heterogeneity, and subgroup analyses were performed according to time, frequency, and event. Results Synthesizing all the trials, the results show that the study heterogeneity of physical exercise on the improvement of depressive mood in college students is relatively high (I2=63%, P<0.01), which has a medium effect (SMD=-0.63, 95% confidence interval=-0.80 to -0.46). The results reveal low heterogeneity in anxious mood (I2=36%, P = 0.04), with a medium effect (SMD=-0.58, 95% confidence interval=-0.71 to -0.44). Conclusion The Meta-Analysis confirms the effective and positive role of physical exercise in reducing depressive and anxious moods of college students. Physical exercise can be used as a non-medical method to improve the mental health state of college students and promote full development. Further research should evaluate the impact of various sports and specific exercise prescriptions on college students' negative emotions, so as to apply them to complementary and alternative therapies.
ABSTRACT
BACKGROUND: The novel coronavirus disease 2019 (COVID-19) was broken out in December 2019 and soon became a global health emergency. Effective treatment for COVID-19 is urgently needed. In the present study, we aimed to evaluate the antiviral effect of Arbidol vs. Chloroquine in treating COVID-19. METHODS: We retrospectively analyzed 62 patients with COVID-19 diagnosed according to the guidelines for diagnosis and treatment of COVID-19 in China. They were divided into two groups depending on the antiviral drugs that they received. Participants in the Arbidol group (n=42) received 0.2 g Arbidol, tid for 10 days,and those in Chloroquine group (n=20) received 500 mg Chloroquine, bid for 10 days. The coronavirus negative conversion time and the length of hospital stay were analyzed and compared between the two groups. RESULTS: There was no significant difference in demographic and clinical characteristics between the two groups. After antiviral treatment, the nasopharyngeal specimen negative conversion time of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the length of hospital stay in the Arbidol group were significantly shorter than those in the Chloroquine group (18.50 vs. 25.05 days, P=0.001; 23.52 vs. 28.75 days, P=0.001). Adverse events observed during the antiviral treatment period were comparable between the two groups. Overall, 3 (7.14%) participants in the Arbidol group and 4 (20.0%) in the Chloroquine group experienced adverse events during antiviral treatment. CONCLUSIONS: These results suggest that Arbidol is advantageous over Chloroquine in terms of the SARS-CoV-2 negative conversion and the length of hospital stay in treating COVID-19 patients.